Glycoconjugate Receptors for P-fimbriated Escherichia coli in the Mouse
نویسندگان
چکیده
منابع مشابه
Novel mechanism of P-fimbriated Escherichia coli virulence in pyelonephritis.
U rinary tract infections (UTI) are among the most frequently encountered community-acquired or nosocomial infections. The disease burden of UTI is estimated to be 150 million cases annually worldwide (1). Catheterassociated UTI is the most frequent source of Gram-negative sepsis in hospitalized patients (2). The spectrum of disease in UTI includes cystitis, pyelonephritis, urosepsis, catheter-...
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Escherichia coli express fimbriae-associated adhesins through which they attach to mucosal cells and activate a cytokine response. The receptors for E. coli P fimbriae are the globoseries of glycosphingolipids; Gal alpha 1-->4Gal beta-containing oligosaccharides bound to ceramide in the outer leaflet of the lipid bilayer. The receptors for type 1 fimbriae are mannosylated glycoproteins rather t...
متن کاملIsolation and characterization of the a-sialyl-p-2,3-galactosyl- specific adhesin from fimbriated Escherichia coli
The a-sialyl-1J-2,3-gaIactosyl-specific adhesin (S adhesin) was isolated from cells of a recombinant Escherichia coli K-12 strain expressing the S-flmbrial adhesin complex. A crude cell extract was partiaUy dissociated into fimbriae and an adhesin-enriched fraction by heating to 7O"C. From the latter, adhesin was purified to apparent homogeneity (by fast protein liquid chromatography, immunoblo...
متن کاملLow urinary counts of P-fimbriated Escherichia coli in presumed acute pyelonephritis.
We report 6 children who showed clinical symptoms and laboratory signs of acute pyelonephritis but in whom bacteriuria was insignificant, with Escherichia coli 10(4)/ml, or less. None of the children had symptoms of other disease. Three of the children who were at first treated inadequately or were not treated with antibiotics developed significant bacteriuria later on (10(5)/ml, or greater). U...
متن کاملA-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli.
Three proanthocyanidin trimers possessing A-type interflavanoid linkages, epicatechin-(4beta-->6)-epicatechin-(4beta-->8, 2beta-->O-->7)-epicatechin (4), epicatechin-(4beta-->8, 2beta-->O-->7)-epicatechin-(4beta-->8)-epicatechin (5), and epicatechin-(4beta-->8)-epicatechin-(4beta-->8, 2beta-->O-->7)-epicatechin (6), were isolated from the ripe fruits of Vaccinium macrocarpon (cranberry) and pre...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.15.9017